PGT – Genetic Testing

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Pre-implantation genetic diagnosis is an exciting development for genetic evaluation of the embryo.

Pre-implantation genetic diagnosis

PGT is an exciting development which allows genetic evaluation of the embryo. Cells can be taken from the developing embryo on the 3rd day or the 5th day after fertilisation. These cells are sent to the genetic laboratory and tested for abnormalities.

PGT

Is available at Cape Fertility since 2003. We are highly experienced in the complex process of embryo biopsy. We collaborate with NextBiosciences:
www.nextbio.co.za

PGT-A

Can detect chromosome abnormalities or chromosomal rearrangements. The aim of PGT is to increase IVF pregnancy rates by testing embryos for these chromosomal abnormalities. Without this kind of testing, embryos are usually chosen based on their visual aspect. With PGT embryo testing, however, embryos are tested further and assessed based on their full chromosome complement. During the procedure all 24 chromosomes are examined – the 22 non-sex chromosomes as well as the two sex ones, X and Y – before the embryo transfer takes place. Embryos that have a normal number of chromosomes are more likely to result in a pregnancy. This allows us to choose better embryos for embryo transfer and is particularly useful in older women or couples who have had repeated failed IVF cycles previously. Gender selection is not allowed in South Africa and illegal according to the National Health Act.

PGT-M

Is a laboratory procedure that is used in conjunction with IVF to help detect single gene diseases. Families affected by an inherited disease can reduce the risk of passing it onto their offspring using IVF with PGT.